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規(guī)格	庫存	目錄價(jià)	會員專享價(jià)	數(shù)量
5 mg	In-stock	￥488.00	登錄后可見	- +
10 mg	In-stock	￥748.00	登錄后可見	- +
25 mg	In-stock	￥1436.00	登錄后可見	- +
50 mg	In-stock	￥2136.00	登錄后可見	- +

規(guī)格

庫存

目錄價(jià)

會員專享價(jià)

數(shù)量

5 mg

In-stock

￥488.00

登錄后可見

- +

10 mg

In-stock

￥748.00

登錄后可見

- +

25 mg

In-stock

￥1436.00

登錄后可見

- +

50 mg

In-stock

￥2136.00

登錄后可見

- +

基本信息

英文名稱	RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
中文名稱	2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制劑II)
CAS號	446859-33-2
分子式	C17H13N5
分子量	287.32
MDL	MFCD09037561
外觀	Light brown to yellow powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.
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相關(guān)文獻(xiàn)

Chemical reprogramming of human somatic cells to pluripotent stem cells.

PMID: 35418683 DOI: 10.1038/s41586-022-04593-5

PMID: 35794374 PMCID: PMC9813375 DOI: 10.1038/s41401-022-00932-4

PMID: 29742392 PMCID: PMC5995754 DOI: 10.1016/j.stemcr.2018.04.009

PMID: 29937202 DOI: 10.1016/j.stem.2018.05.025

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2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制劑II)