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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
10 mg	In-stock	￥288.00	登錄后可見	- +
25 mg	In-stock	￥500.00	登錄后可見	- +
50 mg	In-stock	￥900.00	登錄后可見	- +
100 mg	In-stock	￥1300.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

10 mg

In-stock

￥288.00

登錄后可見

- +

25 mg

In-stock

￥500.00

登錄后可見

- +

50 mg

In-stock

￥900.00

登錄后可見

- +

100 mg

In-stock

￥1300.00

登錄后可見

- +

基本信息

英文名稱	Nintedanib Ethanesulfonate Salt (Synonyms: Intedanib; BIBF 1120)
中文名稱	(Z)-3-(((4-(N-甲基-2-(4-甲基哌嗪-1-基)乙酰氨基)苯基)氨基)(苯基)亞甲基)-2-氧代吲哚啉-6-羧酸甲酯乙磺酸鹽; 尼達尼布乙磺酸鹽
CAS號	656247-18-6
分子式	C31H33N5O4.C2H6O3S
分子量	649.76 \| 539.64(free)
MDL	MFCD26142360
外觀	Yellow powder
儲存條件	4°C, sealed storage, away from moisture

產(chǎn)品詳情

BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively).1 It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM). BIBF 1120 inhibits growth factor-dependent proliferation of human umbilical vascular endothelial cells (HUVECs), human microvascular skin endothelial cells (HSMECs), human umbilical artery smooth muscle cells (HUASMCs), and bovine retinal pericytes (BRPs; EC50s = 7-290 nM). In vivo, BIBF 1120 (100 mg/kg) reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model. It also inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model. Formulations containing BIBF 1120 have been used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer (NSCLC).