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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
500 mg	In-stock	￥898.00	登錄后可見(jiàn)	- +
1 g	In-stock	￥1488.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

500 mg

In-stock

￥898.00

登錄后可見(jiàn)

- +

1 g

In-stock

￥1488.00

登錄后可見(jiàn)

- +

基本信息

英文名稱	Nintedanib (Synonyms: BIBF 1120; Intedanib)
中文名稱	(Z)-3-(((4-(N-甲基-2-(4-甲基哌嗪-1-基)乙酰氨基)苯基)氨基)(苯基)亞甲基)-2-氧代吲哚啉-6-羧酸甲酯; 尼達(dá)尼布
CAS號(hào)	656247-17-5
分子式	C31H33N5O4
分子量	539.62
MDL	MFCD11974012
外觀	Yellow crystalline powder

產(chǎn)品詳情

Nintedanib, also known as BIBF 1120, is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). Intedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration.
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相關(guān)文獻(xiàn)

Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).

PMID: 19522465 DOI: 10.1021/jm900431g

Cancer Res, 2008, 68(12), 4774-4782.

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